Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 280
interventional 214
Observational 60
Registry 6

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 43
Drug|placebo 35
Other 32
Device 31
Procedure 14
Biological|placebo 12
Biological 10
Behavioral 9
Device|Drug 5
Drug|Other 4
Behavioral|Other 2
Biological|Drug 2
Device|Other 2
Behavioral|Device 1
Behavioral|Diagnostic Test|Other 1
Biological|Other 1
Biological|Procedure 1
Combination Product 1
Combination Product|Drug 1
Device|Procedure 1
Diagnostic Test 1
Dietary Supplement|Drug 1
Drug|Other|placebo 1
Drug|Procedure 1
Other|placebo 1
placebo 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 49
NA 15
Turkey 12
France 10
Korea, Republic of 9
United Kingdom 8
Pakistan 7
Spain 7
Taiwan 7
Brazil 6
Belgium 5
Canada 5
China 4
Egypt 3
Italy 3
Japan 3
Netherlands 3
United States|Canada 3
United States|Russian Federation|Ukraine 3
Germany 2
Sweden 2
Switzerland 2
United States|Australia|Belgium|Czechia|France|Hungary|Italy|Poland|Portugal|Russian Federation|Slovakia 2
United States|Canada|Hungary|Korea, Republic of|Philippines|Poland|Russian Federation|Thailand|Turkey 2
United States|Chile|France|Mexico|Poland|Turkey 2
United States|Hungary|Italy|Korea, Republic of|Philippines|Poland|Russian Federation|Thailand|Turkey 2
Australia 1
Austria 1
Austria|Czechia|Estonia|Germany|Israel|Korea, Republic of|Poland|Romania|Russian Federation|Slovakia|Turkey|Ukraine 1
Austria|France|Germany|Italy|Portugal|Spain|Switzerland|United Kingdom 1
Belarus|Bosnia and Herzegovina|Bulgaria|Croatia|Moldova, Republic of|Poland|Serbia 1
Canada|Germany|Sweden|United Kingdom 1
Colombia 1
Cyprus 1
Czech Republic 1
Czech Republic|Hungary|Poland 1
Czechia|Austria|Estonia|France|Germany|Israel|Korea, Republic of|Poland|Romania|Russian Federation|Slovakia|Spain|Turkey|Ukraine 1
Czechia|Germany|Hungary|Poland|Spain 1
Czechia|Israel|United Kingdom 1
Denmark 1
France|Norway|Poland 1
Hong Kong|Malaysia|Philippines|Singapore|Thailand 1
Iran, Islamic Republic of 1
Israel 1
Malaysia|Philippines|Singapore|Thailand 1
Norway 1
Peru 1
Poland 1
Romania 1
Russian Federation 1
Thailand 1
Ukraine 1
United States|Argentina|Mexico|Poland|Russian Federation|Ukraine 1
United States|Australia|Belgium|Czechia|France|Germany|Italy|Poland|Russian Federation|Spain|Switzerland|United Kingdom 1
United States|Austria|Belgium|Germany|Italy|Netherlands|Slovenia|Spain|United Kingdom 1
United States|Belgium|Czechia|Israel|Mexico|Poland|Spain|Turkey 1
United States|Canada|Czech Republic|France|Germany|Italy|Poland|Russian Federation|Spain 1
United States|Canada|Czech Republic|Germany|Hungary|Korea, Republic of|Poland|Russian Federation|United Kingdom 1
United States|Canada|Estonia|Latvia|Ukraine 1
United States|Canada|France|Germany|Italy|Norway|Portugal|Spain 1
United States|Czech Republic|Germany|Hungary|India|Poland|Russian Federation 1
United States|Czech Republic|Hungary|Poland 1
United States|Czechia|France|Russian Federation 1
United States|Germany|Hungary|Russian Federation|Ukraine 1

Sites per Study

Site_count Study_Count
1 142
2 14
3 3
4 7
5 1
6 2
7 1
8 1
11 3
12 1
13 3
14 1
16 1
17 1
18 1
19 1
20 1
23 1
25 1
27 2
28 1
29 1
30 2
31 2
32 1
33 1
35 1
38 1
39 1
41 1
43 1
45 2
47 1
48 2
50 1
51 1
53 3
56 1
62 1
73 1

Phase

Phase Study_Count
N/A 96
Phase 3 57
Phase 4 24
Phase 2 23
Phase 1/Phase 2 5
Phase 1 4
Phase 2/Phase 3 4
Early Phase 1 1

Number of Arms

Number_of_Arms Count_of_Studies
1 38
2 122
3 31
4 6
5 1
11 1
NA 15

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 10 4.00000 9.00 20.0 12.00000 23.0 16.0000 10.00000
1st Qu. 10 21.00000 12.00 26.0 37.00000 47.0 120.0000 30.00000
Median 10 32.00000 15.00 30.0 62.00000 57.5 204.0000 60.50000
Mean 10 42.88542 27.25 33.4 82.09524 102.5 223.4912 92.33333
3rd Qu. 10 48.00000 30.25 30.0 128.00000 113.0 351.0000 124.50000
Max. 10 300.00000 70.00 61.0 279.00000 272.0 600.0000 300.00000

Trial Group Type

group_type Group_Count
Experimental 200
Active Comparator 107
Placebo Comparator 54
No Intervention 18
Other 18
Sham Comparator 18
NA 15

Intervention Model

intervention_model Study_Count
Parallel Assignment 132
Single Group Assignment 44
Crossover Assignment 32
NA 4
Factorial Assignment 1
Sequential Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 188
Supportive Care 8
Basic Science 6
Other 5
Diagnostic 4
Health Services Research 1
Prevention 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 18
NA 8
Spain 6
Turkey 4
Canada 3
France 3
Australia|Austria|Belgium|China|Czech Republic|Denmark|Finland|France|Germany|Italy|Korea, Republic of|Malaysia|Mexico|Philippines|Portugal|Russian Federation|Singapore|Spain|Sweden|Taiwan|Thailand|United Kingdom 1
Austria 1
Austria|France|Germany|Netherlands|Switzerland 1
Austria|Switzerland 1
Belgium 1
Brazil 1
Chile 1
Czechia 1
Denmark 1
France|Germany|Russian Federation 1
Germany 1
Italy 1
Korea, Republic of 1
Portugal 1
Taiwan 1
United States|Australia|Austria|Brazil|France|Germany|Hong Kong|Italy|Mexico|Philippines|Poland|Portugal|Russian Federation|Taiwan 1
United States|Canada|France|Germany|Italy|Poland|Russian Federation 1
United States|France|Germany|Italy|Spain|Taiwan|United Kingdom 1

Sites per Study

Site_count Study_Count
1 44
2 2
3 3
5 1
11 1
17 1
24 1
27 1
28 1
36 2
55 1
57 1
96 1

Enrollment Metrics

Measure Observational
Min 5.0000
1st Qu 39.0000
Median 62.5000
Mean 224.2333
3rd Qu 256.5000
Max 1388.0000

Observation Model

observational_model Study_Count
Cohort 28
Case-Only 9
NA 9
Other 6
Case-Control 3
Case-Crossover 2
Ecologic or Community 2
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 37
Cross-Sectional 10
NA 7
Retrospective 4
Other 2

Registries

Studies by Country

Country Study_Count
Austria|Germany 1
Chile 1
China 1
Poland 1
Spain 1
United States|Australia 1

Sites per Study

Site_count Study_Count
1 3
2 1
6 1
12 1

Enrollment Metrics

Measure Registries
Min 51.000
1st Qu 102.000
Median 304.000
Mean 3793.167
3rd Qu 1625.000
Max 20000.000

Registry Model

observational_model Study_Count
Cohort 4
Case-Only 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 4
Cross-Sectional 1
Other 1

Follow-up

target_duration Study_Count
20 Years 2
1 Year 1
100 Years 1
8 Weeks 1
9 Months 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04099667 An Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity Followed by an Open-Label Multiple-Treatment Safety Study https://ClinicalTrials.gov/show/NCT04099667 Active, not recruiting US WorldMeds LLC 2022-03-31
NCT03405948 Efficiency of Botulinum Toxin Injection for Spastic Equinovarus Foot in Post Stroke Hemiparetic Patients https://ClinicalTrials.gov/show/NCT03405948 Completed Assistance Publique Hopitaux De Marseille 2009-05-18
NCT03379038 Role Of Physical Therapy In Relieving Constipation In Children With Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03379038 Completed Isra University 2019-01-20
NCT03367429 The Movement of Botulinum Toxin Through the Lateral Gastrocnemius Muscle in Humans: An Expanded Examination https://ClinicalTrials.gov/show/NCT03367429 Recruiting Weill Medical College of Cornell University 2020-10-31
NCT03822923 Neurodynamics on Spasticity in Upper Extremity of Stroke Patients. https://ClinicalTrials.gov/show/NCT03822923 Completed Riphah International University 2019-07-20
NCT03821402 Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Adult Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT03821402 Recruiting Revance Therapeutics, Inc. 2020-08-24
NCT03342820 Impact of Muscular Fatigability on Spastic Co-contractions After Stroke Patients https://ClinicalTrials.gov/show/NCT03342820 Completed University Hospital, Lille 2019-10-10
NCT03321097 Condensed and Distributed Robotic Therapy in Spastic Stroke Post Botulinum Toxin Injection https://ClinicalTrials.gov/show/NCT03321097 Completed Chang Gung Memorial Hospital 2019-05-07
NCT03319732 A Study to Evaluate the Long-term Safety of Arbaclofen Extended-Release Tablets for Patients With Spasticity Due to MS https://ClinicalTrials.gov/show/NCT03319732 Active, not recruiting Osmotica Pharmaceutical US LLC 2020-02-29
NCT03290131 A Study to Investigate the Safety and Effectiveness of Arbaclofen Extended-Release Tablets for Patients With MS https://ClinicalTrials.gov/show/NCT03290131 Completed Osmotica Pharmaceutical US LLC 2018-12-03
NCT03289702 CORETOX® in Treatment of Post Stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT03289702 Completed Medy-Tox 2018-06-30
NCT03261167 A Phase III Study to Evaluate the Efficacy and Safety of GSK1358820 in Subjects With Post-stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT03261167 Completed GlaxoSmithKline 2018-03-20
NCT03240601 Spinal Cord Stimulation to Augment Activity Based Therapy https://ClinicalTrials.gov/show/NCT03240601 Completed Shepherd Center, Atlanta GA 2019-09-11
NCT03212846 Muscle Spasticity Reduction in Children With Cerebral Palsy by Means of Hippotherapy https://ClinicalTrials.gov/show/NCT03212846 Completed University of Cadiz 2016-10-31
NCT03206190 The Pre-SPG4 Study https://ClinicalTrials.gov/show/NCT03206190 Recruiting University Hospital Tuebingen 2027-05-31
NCT03166930 Evaluation of a Spasticity Management Program for People With Multiple Sclerosis https://ClinicalTrials.gov/show/NCT03166930 Recruiting VA Office of Research and Development 2020-12-31
NCT03166293 Early Intensive Exercise to Improve Walking in Children With Spastic Diplegia https://ClinicalTrials.gov/show/NCT03166293 Active, not recruiting University of Alberta 2019-01-04
NCT03131791 Comparing the Radial Extracorporeal Shock Waves and Botulinum Toxin Injection for Spasticity https://ClinicalTrials.gov/show/NCT03131791 Completed Mackay Memorial Hospital 2017-07-01
NCT03096197 Exoskeleton and Spinal Cord Stimulation for SCI https://ClinicalTrials.gov/show/NCT03096197 Recruiting Kessler Foundation 2020-09-30
NCT03080454 The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke https://ClinicalTrials.gov/show/NCT03080454 Completed Northwell Health 2018-03-31
NCT03044080 Effects of Botulinum Neurotoxin Type A (BoNT/A) Free of Complexing Proteins in the Spastic Equinovarus Foot https://ClinicalTrials.gov/show/NCT03044080 Completed Parc de Salut Mar 2017-06-30
NCT03024190 Kinesiotaping Combined With Therapeutic Exercise in Upper Extremity Spasticity and Function in Subacute Stroke Patients https://ClinicalTrials.gov/show/NCT03024190 Completed Chang Gung Memorial Hospital 2018-07-31
NCT03005938 Influence of the Spinal Manipulation on Muscle Spasticity and Manual Dexterity in Cerebral Palsy. https://ClinicalTrials.gov/show/NCT03005938 Completed International Clinic of Rehabilitation, Ukraine 2017-09-15
NCT02969356 Study to Evaluate Effects of DYSPORT® Injected in Lower and Upper Limb Combined With Guided Self-Rehabilitation Contract (GSC) https://ClinicalTrials.gov/show/NCT02969356 Completed Ipsen 2018-04-26
NCT02944929 The Effect of a Self-rehabilitation Program in Addition to Usual Treatment for Spasticity on Impairment and Activity Limitation in Patients With Spastic Hemiparesis Following Stroke https://ClinicalTrials.gov/show/NCT02944929 Recruiting Assistance Publique - Hôpitaux de Paris 2020-12-31
NCT02934646 Powered Exoskeleton for the Treatment of Elbow Spasticity https://ClinicalTrials.gov/show/NCT02934646 Completed Auxilium Vitae Volterra 2016-07-31
NCT02917330 Stretching and Strength Training for Improved Gait Function in Children With Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT02917330 Completed Oslo University Hospital 2016-10-31
NCT02907775 Multi-channel Stimulation for Post Stroke Spasticity (MUSTS) https://ClinicalTrials.gov/show/NCT02907775 Completed Sheffield Teaching Hospitals NHS Foundation Trust 2018-09-30
NCT02903823 Intrathecal (IT) Baclofen Drug Distribution https://ClinicalTrials.gov/show/NCT02903823 Active, not recruiting Vanderbilt University Medical Center 2019-03-15
NCT02757404 Meditoxin® Treatment in Patients With Post Stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT02757404 Completed Medy-Tox 2016-08-16
NCT02749591 Comparative Hybrid Effects of Combining BoNT-A With Robot-assisted or Mirror Therapy for U/E Spasticity Stroke Patients https://ClinicalTrials.gov/show/NCT02749591 Completed Chang Gung Memorial Hospital 2017-11-30
NCT02719483 Radial Extracorporeal Shock Wave Therapy for Spastic Plantar Flexor Muscles in Young Children With Cerebral Palsy https://ClinicalTrials.gov/show/NCT02719483 Completed First Hospital of Jilin University 2015-07-31
NCT02718690 Importance of the Current Density in TENS https://ClinicalTrials.gov/show/NCT02718690 Completed University of Castilla-La Mancha 2015-02-28
NCT02655471 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection https://ClinicalTrials.gov/show/NCT02655471 Completed Universidad Peruana Cayetano Heredia 2019-03-15
NCT02643160 Analyzing the Effect of Trunk Training on Limbs in Children With Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT02643160 Completed Abant Izzet Baysal University 2015-10-31
NCT02604186 Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia https://ClinicalTrials.gov/show/NCT02604186 Completed University of Campinas, Brazil 2017-03-15
NCT02566837 Use of Ultrasound in Injections of Botulinum Toxin https://ClinicalTrials.gov/show/NCT02566837 Completed University Hospital, Toulouse 2015-02-28
NCT02546999 Does Botulinum Toxin A Make Walking Easier in Children With Cerebral Palsy? https://ClinicalTrials.gov/show/NCT02546999 Recruiting St. Olavs Hospital 2020-12-31
NCT02542787 Study of VSN16R for the Treatment of Spasticity in Multiple Sclerosis https://ClinicalTrials.gov/show/NCT02542787 Completed Canbex Therapeutics Ltd 2017-10-31
NCT02462317 Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment https://ClinicalTrials.gov/show/NCT02462317 Recruiting University Hospital, Toulouse 2020-09-30
NCT02460406 Progressive Functional Strength Training in Unilateral Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT02460406 Completed Hacettepe University 2015-04-30
NCT02458612 Effects of Mirror Therapy Combined With Progressive Strength Training in Unilateral Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT02458612 Completed Hacettepe University 2016-11-30
NCT02418949 Altering Activation Patterns Post-stroke https://ClinicalTrials.gov/show/NCT02418949 Active, not recruiting Shirley Ryan AbilityLab 2020-10-31
NCT02400619 Shockwaves Therapy and Botulinum Toxin for the Treatment of Spasticity in Patients With Cerebral Palsy. A Cross Over RCT https://ClinicalTrials.gov/show/NCT02400619 Completed University Ramon Llull 2015-06-30
NCT02377804 Dry Needling for Spasticity in Stroke https://ClinicalTrials.gov/show/NCT02377804 Completed Universidad Rey Juan Carlos 2015-04-30
NCT02358005 Optimal Dose of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spasticity https://ClinicalTrials.gov/show/NCT02358005 Recruiting Yonsei University 2019-08-31
NCT02334683 Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia https://ClinicalTrials.gov/show/NCT02334683 Recruiting Icahn School of Medicine at Mount Sinai 2020-08-31
NCT02326818 Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and Spasticity https://ClinicalTrials.gov/show/NCT02326818 Completed National Institutes of Health Clinical Center (CC) 2020-03-26
NCT02321436 Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression https://ClinicalTrials.gov/show/NCT02321436 Completed Ipsen 2016-03-31
NCT02314208 Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 https://ClinicalTrials.gov/show/NCT02314208 Completed Institut National de la Santé Et de la Recherche Médicale, France 2017-09-27
NCT02291159 Effects of DNHS Technique in the Treatment of Upper Limb Spasticity and Function in Stroke https://ClinicalTrials.gov/show/NCT02291159 Completed Universidad San Jorge 2014-12-31
NCT02280083 A Study to Evaluate the Botulinum Toxin Type A for Injection(HengLi®) in Subjects With Post-stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT02280083 Completed Lanzhou Institute of Biological Products Co., Ltd 2016-02-29
NCT02268461 Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Post-Stroke Spasticity https://ClinicalTrials.gov/show/NCT02268461 Completed University of Minnesota 2016-10-31
NCT02261142 Efficacy and Cost-effectiveness of Spasticity Treatment With Multifocal TENS https://ClinicalTrials.gov/show/NCT02261142 Completed Linkoeping University 2015-02-28
NCT02221011 The Effect of Extracorporeal Shock Wave Therapy on Spasticity https://ClinicalTrials.gov/show/NCT02221011 Completed Tri-Service General Hospital 2015-06-30
NCT02203994 Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury https://ClinicalTrials.gov/show/NCT02203994 Completed Swiss Paraplegic Centre Nottwil 2016-10-31
NCT02188277 Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy https://ClinicalTrials.gov/show/NCT02188277 Completed Merz Pharmaceuticals GmbH 2016-12-31
NCT02170779 Developing and Testing a Comprehensive MS Spasticity Management Program https://ClinicalTrials.gov/show/NCT02170779 Completed VA Office of Research and Development 2016-05-31
NCT02027025 Study of SPARC1103 in Subjects With Spasticity https://ClinicalTrials.gov/show/NCT02027025 Completed Sun Pharma Advanced Research Company Limited 2017-04-28
NCT02106351 Efficacy And Safety Of Dysport In The Treatment Of Upper Limb Spasticity In Children https://ClinicalTrials.gov/show/NCT02106351 Completed Ipsen 2017-09-21
NCT02073513 Kinesiotaping the Hand in Cerebral Palsy https://ClinicalTrials.gov/show/NCT02073513 Completed Hacettepe University 2010-09-30
NCT01313767 MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT01313767 Completed Medy-Tox 2012-01-31
NCT01278576 Botulinum Toxin A Adult Gastrocnemius Muscle Study https://ClinicalTrials.gov/show/NCT01278576 Completed The Catholic University of Korea 2011-12-31
NCT02052024 Myobloc Atrophy Study https://ClinicalTrials.gov/show/NCT02052024 Completed Georgetown University 2015-08-31
NCT04171232 Effect of Augmented Reality Intervention on the Range of Motion, Muscle Strength, Function of Upper Extremity and Balance in Children With Spastic Hemiplegic Cerebral Palsy: A Randomized Clinical Trial https://ClinicalTrials.gov/show/NCT04171232 Completed Zohra Institute of Health Sciences 2020-03-15
NCT02010736 Loading Gait in Spatic Cerebral Palsy https://ClinicalTrials.gov/show/NCT02010736 Completed Universidade Federal do Rio Grande do Norte 2012-10-31
NCT02002884 Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy https://ClinicalTrials.gov/show/NCT02002884 Completed Merz Pharmaceuticals GmbH 2017-07-04
NCT01968902 Safety of Xeomin for Lower Limb Spasticity in Multiple Sclerosis Patients https://ClinicalTrials.gov/show/NCT01968902 Completed Multiple Sclerosis Center of Northeastern New York 2016-01-27
NCT01964547 A Randomized Study of Sativex on Cognitive Function and Mood: Multiple Sclerosis Patients https://ClinicalTrials.gov/show/NCT01964547 Completed GW Pharmaceuticals Ltd. 2013-05-31
NCT01915459 Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT01915459 Completed Hugel 2014-05-31
NCT01915342 Developing Optimal Focal Muscle Vibration for Improving Spasticity https://ClinicalTrials.gov/show/NCT01915342 Completed Seoul National University Hospital 2014-03-31
NCT01905683 Long-term Open-label Study of Botulinumtoxin Type A to Treat Spasticity of Leg(s) or Leg(s) and Arm in Cerebral Palsy https://ClinicalTrials.gov/show/NCT01905683 Completed Merz Pharmaceuticals GmbH 2017-01-31
NCT01898520 A Safety, Efficacy and Tolerability Study of Sativex for the Treatment of Spasticity in Children Aged 8 to 18 Years https://ClinicalTrials.gov/show/NCT01898520 Completed GW Research Ltd 2016-09-30
NCT01893411 Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Leg(s) in Cerebral Palsy https://ClinicalTrials.gov/show/NCT01893411 Completed Merz Pharmaceuticals GmbH 2015-08-31
NCT01882556 Early Use of Botulinum Toxin in Spasticity Post Stroke. https://ClinicalTrials.gov/show/NCT01882556 Completed Sandwell & West Birmingham Hospitals NHS Trust 2014-05-31
NCT01863901 Study Evaluating Treatment of Upper Limb Spasticity Using the Cryo-Touch III Device https://ClinicalTrials.gov/show/NCT01863901 Completed Pacira CryoTech, Inc., a wholly owned subsidiary of Pacira BioSciences, Inc. 2013-07-31
NCT01844232 One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spasticity https://ClinicalTrials.gov/show/NCT01844232 Completed Osmotica Pharmaceutical US LLC 2014-12-31
NCT01839279 A Study to Define the ECG Effects of Tizanidine Compared to Placebo and the Positive Control, Moxifloxacin, in Healthy Men and Women Using a Blinded ECG Evaluator: A Thorough ECG Trial https://ClinicalTrials.gov/show/NCT01839279 Completed Acorda Therapeutics 2014-02-28
NCT01803464 Effect of Botox and Vibration on Bone in Children With Cerebral Palsy https://ClinicalTrials.gov/show/NCT01803464 Completed University of Delaware 2015-02-28
NCT01797185 Safety Study of SPARC1104 https://ClinicalTrials.gov/show/NCT01797185 Completed Sun Pharma Advanced Research Company Limited 2017-07-31
NCT01776970 Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease https://ClinicalTrials.gov/show/NCT01776970 Completed Ospedale San Raffaele 2015-12-31
NCT01751373 Assessment and Management of Post-Stroke Spasticity With Botulinum Toxin-A https://ClinicalTrials.gov/show/NCT01751373 Completed Sunnybrook Health Sciences Centre 2014-11-30
NCT01743651 Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosis https://ClinicalTrials.gov/show/NCT01743651 Completed Osmotica Pharmaceutical US LLC 2014-04-30
NCT01683838 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury https://ClinicalTrials.gov/show/NCT01683838 Completed Acorda Therapeutics 2003-11-30
NCT01651819 Urological Physical Therapy in HTLV-1 With Urinary Symptoms https://ClinicalTrials.gov/show/NCT01651819 Completed Hospital Universitário Professor Edgard Santos 2014-12-30
NCT01603641 BOTOX® Open-Label Treatment in Pediatric Lower Limb Spasticity https://ClinicalTrials.gov/show/NCT01603641 Completed Allergan 2018-08-25
NCT01603615 BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT01603615 Completed Allergan 2018-09-03
NCT01603602 BOTOX® Treatment in Pediatric Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT01603602 Completed Allergan 2017-06-29
NCT01603459 Efficacy and Safety Dose Titration Study of Botulinum Toxin Type A to Treat Spasticity in the Leg and Arm https://ClinicalTrials.gov/show/NCT01603459 Completed Merz Pharmaceuticals GmbH 2014-09-30
NCT01575054 BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity https://ClinicalTrials.gov/show/NCT01575054 Completed Allergan 2014-09-30
NCT01538225 Neurophysiological Study of Sativex in Multiple Sclerosis (MS) Spasticity https://ClinicalTrials.gov/show/NCT01538225 Completed Almirall, S.A. 2013-11-30
NCT01520545 Safety Study of 3 mg/mL Baclofen Injection (Intrathecal) Using A Programmable Pump https://ClinicalTrials.gov/show/NCT01520545 Completed Piramal Critical Care, Ltd. 2016-08-31
NCT01472263 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases https://ClinicalTrials.gov/show/NCT01472263 Completed Hospital Universitário Professor Edgard Santos 2012-09-30
NCT01464307 Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Leg After a Stroke https://ClinicalTrials.gov/show/NCT01464307 Completed Merz Pharmaceuticals GmbH 2014-08-31
NCT01457352 Efficacy and Safety of SPARC0921 in Subjects With Spasticity https://ClinicalTrials.gov/show/NCT01457352 Completed Sun Pharma Advanced Research Company Limited 2017-08-25
NCT01448980 Efficacy of Massage in Stroke Spasticity https://ClinicalTrials.gov/show/NCT01448980 Completed Mahidol University 2014-06-30
NCT01412008 Exploring Advanced Imaging Techniques to Characterize Botulinum Toxin Diffusion in Human Muscle https://ClinicalTrials.gov/show/NCT01412008 Completed New York Presbyterian Hospital 2012-06-30
NCT01392300 Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Arm After a Stroke https://ClinicalTrials.gov/show/NCT01392300 Completed Merz Pharmaceuticals GmbH 2013-03-31
NCT01367327 Effects of Therapeutic Music Combined With Loaded Sit-to-Stand Resistance Exercise for Children With Spastic Diplegia https://ClinicalTrials.gov/show/NCT01367327 Completed National Taiwan University Hospital 2011-12-31
NCT04415346 A Single Center, Phase I Clinical Trial to Evaluate the Safety of LIZTOX Inj in the Treatment of Post Stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT04415346 Enrolling by invitation Huons Co., Ltd. 2020-06-30
NCT04322825 Mollii - Personalized Suit for Treatment of Spasticity, GFMCS 3-5 https://ClinicalTrials.gov/show/NCT04322825 Completed Hvidovre University Hospital 2019-07-01
NCT04316026 Effectiveness of Shock Wave Therapy for Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT04316026 Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain 2020-06-30
NCT04310995 Different Anti-Spastic Therapy Strategies After CABG Using Radial Artery Grafts https://ClinicalTrials.gov/show/NCT04310995 Recruiting Ruijin Hospital 2021-12-31
NCT04286191 Physiological Changes Induced Through MEP Conditioning in People With SCI https://ClinicalTrials.gov/show/NCT04286191 Recruiting Medical University of South Carolina 2025-03-31
NCT04256681 SNAP: Measurement of the Subjective Perception of the Symptom in Hereditary Spastic Paraparesis (HSP) https://ClinicalTrials.gov/show/NCT04256681 Recruiting IRCCS Eugenio Medea 2020-07-30
NCT04222049 Application of Vibration Wave Therapy to the Children Suffering From Cerebral Palsy and Tongue Spastic Dysarthria https://ClinicalTrials.gov/show/NCT04222049 Completed National University of Science and Technology, Pakistan 2020-05-12
NCT04190238 Efficiency of the Super Inductive System in Spasticity Treatment https://ClinicalTrials.gov/show/NCT04190238 Recruiting Universitatea de Medicina si Farmacie Iuliu Hatieganu 2021-12-31
NCT04180098 Improving Gait Adaptability in Hereditary Spastic Paraplegia https://ClinicalTrials.gov/show/NCT04180098 Recruiting Radboud University 2021-05-31
NCT04160403 The Socioeconomic Status and Child Characteristics on the Physical Therapy Outcome in Children With Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT04160403 Completed Cairo University 2019-07-23
NCT04154566 Influence of Aerobic Exercise on Inhibitory Control of Excutive Function in Spastic Hemiplegic C.P https://ClinicalTrials.gov/show/NCT04154566 Completed South Valley University 2019-07-01
NCT04101643 PCSK9 Inhibitor Treatment for Patients With SPG5 https://ClinicalTrials.gov/show/NCT04101643 Recruiting First Affiliated Hospital of Fujian Medical University 2020-05-03
NCT04087330 Whole-body Vibration in Spastic Hemiplegic Cerebral Palsy https://ClinicalTrials.gov/show/NCT04087330 Completed Riphah International University 2020-01-01
NCT04076878 Effects of Using the Electrodress Mollii on Spasticity https://ClinicalTrials.gov/show/NCT04076878 Completed Danderyd Hospital 2019-02-01
NCT04063995 Repetitive Transcranial Magnetic Stimulation in Post Stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT04063995 Recruiting Izmir Katip Celebi University 2021-06-30
NCT04054141 rTMS in Treatment of Spasticity https://ClinicalTrials.gov/show/NCT04054141 Recruiting Hospital for Special Surgery, New York 2020-09-01
NCT04015362 Pulsed Magnetic Stimulation - Managing Spasticity in Spinal Cord Injury https://ClinicalTrials.gov/show/NCT04015362 Recruiting Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust 2020-10-31
NCT04005937 Optimal Interstimulus Interval For Consecutive H-Reflex Responses In Patients With Spasticity https://ClinicalTrials.gov/show/NCT04005937 Completed Istanbul Physical Medicine Rehabilitation Training and Research Hospital 2019-07-17
NCT03992404 Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury https://ClinicalTrials.gov/show/NCT03992404 Active, not recruiting Merz Pharmaceuticals GmbH 2023-06-30
NCT03961906 Physiotherapy in Hereditary Spastic Paraplegia https://ClinicalTrials.gov/show/NCT03961906 Completed University Hospital Tuebingen 2017-03-30
NCT03932591 The Effect of Inhibitory Kinesio Taping Application on Spasticity, Stretch Reflex and Motor Neuron Activity https://ClinicalTrials.gov/show/NCT03932591 Enrolling by invitation Istanbul Physical Medicine Rehabilitation Training and Research Hospital 2020-12-16
NCT03931824 Efficacy Of Platelet Rich Plasma In The Treatment Of Hemiplegıc Shoulder Pain https://ClinicalTrials.gov/show/NCT03931824 Completed Ege University 2015-11-18
NCT03916770 The Effect of Whole Body Vibration (WBV) on Spasticity in Poststroke Hemiplegia https://ClinicalTrials.gov/show/NCT03916770 Recruiting Istanbul Physical Medicine Rehabilitation Training and Research Hospital 2020-03-01
NCT03910101 The Effect of Spasticity-correcting Hand Surgery for Spasticity Related Symptoms https://ClinicalTrials.gov/show/NCT03910101 Recruiting Vastra Gotaland Region 2021-03-10
NCT03908580 MEDITOXIN® Treatment in Subjects With Post-Stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT03908580 Completed Medy-Tox 2014-10-31
NCT03906305 Dry Needling and Bobath Treatment Clinical Effects Focused on Stroke Patients https://ClinicalTrials.gov/show/NCT03906305 Completed Universidad Rey Juan Carlos 2019-10-15
NCT03863678 Effects of Dry Needling on Spasticity, Functions, Balance and Independence Level in Patients With Stroke https://ClinicalTrials.gov/show/NCT03863678 Completed Eastern Mediterranean University 2019-12-01
NCT03863197 Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03863197 Recruiting Universitaire Ziekenhuizen Leuven 2019-06-01
NCT03856905 Extracorporeal Shock Wave Therapy Versus Functional Electrical Stimulation on Spasticity, Function and Gait Parameters in Hemiplegic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03856905 Completed Cairo University 2019-04-10
NCT03815721 Carry-over Effects of Repetitively Applied Transcutaneous Spinal Cord Stimulation on Spasticity https://ClinicalTrials.gov/show/NCT03815721 Recruiting Swiss Paraplegic Centre Nottwil 2023-12-31
NCT03814889 Passive Tactile Stimulation for Stroke Rehabilitation https://ClinicalTrials.gov/show/NCT03814889 Recruiting Stanford University 2021-01-30
NCT03795974 Efficacy of Allogeneic Umbilical Cord Derived Hematopoietic and Mesenchymal Stem Cells in Cerebral Palsy https://ClinicalTrials.gov/show/NCT03795974 Active, not recruiting Tehran University of Medical Sciences 2019-10-31
NCT03771599 The Effects of Traditional Massage on Spasticity and Activity of Children(2 to 10 Years) With Cerebral Palsy https://ClinicalTrials.gov/show/NCT03771599 Recruiting Isra University 2019-01-30
NCT03756974 BX-1 in Spasticity Due to Multiple Sclerosis https://ClinicalTrials.gov/show/NCT03756974 Recruiting Bionorica SE 2020-07-31
NCT03747900 Dry Needling and Botulinum Toxin in the Management of Poststroke Spasticity https://ClinicalTrials.gov/show/NCT03747900 Completed Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey 2018-03-30
NCT03744884 Movement Characterization in Spastic/Dystonic Cerebral Palsy Using Haptic Feedback in Virtual Reality https://ClinicalTrials.gov/show/NCT03744884 Recruiting University of Illinois at Urbana-Champaign 2021-01-01
NCT03797573 Multichannel tDCS to Reduce Hypertonia in Patients With Prolonged DOC https://ClinicalTrials.gov/show/NCT03797573 Completed University of Liege 2014-06-28
NCT03710343 Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study https://ClinicalTrials.gov/show/NCT03710343 Recruiting Holland Bloorview Kids Rehabilitation Hospital 2022-06-01
NCT03708757 Effect of Post Isometric Relaxation Technique & Eccentric Muscle Contraction on Hamstring Spasticity in CP https://ClinicalTrials.gov/show/NCT03708757 Completed Riphah International University 2019-03-30
NCT03704155 Effect of Botulinum Toxin Type A Associated With Physical Therapy on Children With Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03704155 Completed University of Nove de Julho 2018-05-31
NCT03627416 Repetitive Transcranial Magnetic Stimulation as Therapy in Hereditary Spastic Paraplegia and Adrenomyeloneuropathy https://ClinicalTrials.gov/show/NCT03627416 Completed Jagiellonian University 2019-01-01
NCT03585569 " Treating MS Patients With Lower Extremity Spasticity Using Dysport" https://ClinicalTrials.gov/show/NCT03585569 Recruiting Neurology Center of New England P.C. 2019-05-31
NCT03549975 Hand Rehabilitation Using Botulinum Toxin and Functional Electrical Stimulation-pilot Study https://ClinicalTrials.gov/show/NCT03549975 Completed National Rehabilitation Center, Seoul, Korea 2017-08-18
NCT03548974 Internet-based MOTOmed Exercise to Reduce Spasticity and Improve Physical Function in Persons With Multiple Sclerosis https://ClinicalTrials.gov/show/NCT03548974 Completed University of Erlangen-Nürnberg 2015-10-31
NCT03546959 Dynamic Lycra Orthosis as an Adjunct to Botulinum Toxin-A Injection for Post-stroke Spasticity https://ClinicalTrials.gov/show/NCT03546959 Completed Marmara University 2019-02-11
NCT03546517 Effectiveness of Dry Needling (DNHS Technique) in Patients With Chronic Stroke https://ClinicalTrials.gov/show/NCT03546517 Completed Universidad San Jorge 2018-07-30
NCT03521076 Randomized Controlled Trial of Virtual Reality https://ClinicalTrials.gov/show/NCT03521076 Enrolling by invitation Gillette Children’s Specialty Healthcare 2021-07-31
NCT03486483 Spastic Cerebral Palsy and Slackline https://ClinicalTrials.gov/show/NCT03486483 Completed University of Oviedo 2015-04-01
NCT03449498 The Effects of Intensive Therapy on Trunk and Lower Limbs in Children With Spastic Cerebral Palsy. https://ClinicalTrials.gov/show/NCT03449498 Completed University Ghent 2019-09-15
NCT03442660 Validation of the Spasticity Related Quality of Life Questionnaire https://ClinicalTrials.gov/show/NCT03442660 Completed Ipsen 2019-08-09
NCT03440632 Functional Electrical Stimulation During Walking in Cerebral Palsy https://ClinicalTrials.gov/show/NCT03440632 Recruiting Maastricht University Medical Center 2021-08-31
NCT01256021 The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy https://ClinicalTrials.gov/show/NCT01256021 Completed Medy-Tox 2011-02-28
NCT01251380 Dysport® Pediatric Lower Limb Spasticity Follow-on Study https://ClinicalTrials.gov/show/NCT01251380 Completed Ipsen 2015-01-31
NCT01251367 Dysport® Adult Lower Limb Spasticity Follow-on Study https://ClinicalTrials.gov/show/NCT01251367 Completed Ipsen 2015-04-30
NCT01249417 Dysport® Pediatric Lower Limb Spasticity Study https://ClinicalTrials.gov/show/NCT01249417 Completed Ipsen 2014-02-28
NCT01249404 Dysport® Adult Lower Limb Spasticity Study https://ClinicalTrials.gov/show/NCT01249404 Completed Ipsen 2013-12-31
NCT01222468 Effect of Cannabinoids on Spasticity and Neuropathic Pain in Spinal Cord Injured Persons https://ClinicalTrials.gov/show/NCT01222468 Completed University of Manitoba 2015-02-28
NCT01205451 A Multicenter, Open-label, Single Dose Study of the Safety and Efficacy of GSK1358820 (Botulinum Toxin Type A) in Chinese Subjects With Post-stroke Focal Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT01205451 Completed GlaxoSmithKline 2011-12-31
NCT01153815 A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GSK1358820 (Botulinum Toxin Type A) in Chinese Subjects With Post-stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT01153815 Completed GlaxoSmithKline 2011-06-30
NCT01153022 Effect of Joint Mobilization on Alpha Motoneuron Reflex Excitability https://ClinicalTrials.gov/show/NCT01153022 Completed Universidad Autónoma de Manizales, Colombia 2009-03-31
NCT01147653 A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy https://ClinicalTrials.gov/show/NCT01147653 Completed Duke University 2016-03-31
NCT01049581 Effects of Pediatric Aquatic Therapy in Children With Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT01049581 Completed Chang Gung Memorial Hospital 2010-07-31
NCT01032239 SISTERS: Spasticity In Stroke Study - Randomized Study https://ClinicalTrials.gov/show/NCT01032239 Completed MedtronicNeuro 2016-09-30
NCT00945295 Efficacy and Safety Study of Botulinum Neurotoxin A With Rehabilitation Versus Botulinum Neurotoxin A Alone in Treatment of Post-stroke Spasticity https://ClinicalTrials.gov/show/NCT00945295 Completed Biomedical Research Institute of New Mexico 2012-05-31
NCT00914290 A Study With IPX056 in Subjects With Spasticity Associated With Multiple Sclerosis https://ClinicalTrials.gov/show/NCT00914290 Completed Impax Laboratories, LLC 2010-01-31
NCT00825097 Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patients https://ClinicalTrials.gov/show/NCT00825097 Completed Cliniques universitaires Saint-Luc- Université Catholique de Louvain 2011-12-31
NCT03901703 The Effects of Functional Strengthening in Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03901703 Completed Gazi University 2019-05-15
NCT03807557 Effects of Robotic Modified Constraint -Induced Therapy on Behavioral Outcomes and Motor-learning Process in Patients With Spastic Hemiplegic Stroke Post Botulinum Toxin Type A Injection https://ClinicalTrials.gov/show/NCT03807557 Enrolling by invitation Chang Gung Memorial Hospital 2020-02-29
NCT01603628 BOTOX® Treatment in Pediatric Lower Limb Spasticity https://ClinicalTrials.gov/show/NCT01603628 Completed Allergan 2017-06-28
NCT04113525 Transcutaneous Spinal and Peripheral Stimulation and Wrist Robotic Therapy for Patients With Spastic Stroke https://ClinicalTrials.gov/show/NCT04113525 Recruiting Northwell Health 2021-12-31
NCT04002843 Variability of the Unique Fiber Potentials of a Spastic Muscle Treated With Botulinum Toxin https://ClinicalTrials.gov/show/NCT04002843 Recruiting Centre Hospitalier Universitaire de Nīmes 2021-09-30
NCT03612128 The Effect of Mirror Therapy on Cerebral Re-organization, Functional Motor Skills, and Quality of Life in Hemiplegic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03612128 Completed Hacettepe University 2016-12-19
NCT03402854 tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03402854 Recruiting Burke Medical Research Institute 2024-06-30
NCT01945684 A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safety and Efficacy of DWP450 Versus Botox® in Treatment of Post Stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT01945684 Completed Daewoong Pharmaceutical Co. LTD. 2014-05-31
NCT04437056 Nerve Transfers in Post-stroke Spasticity https://ClinicalTrials.gov/show/NCT04437056 Enrolling by invitation Medical University of Vienna 2023-12-31
NCT03534856 Sensorimotor Changes in Stroke Following Mindfulness https://ClinicalTrials.gov/show/NCT03534856 Completed University of Southern California 2017-02-17
NCT00723866 Botulinum Toxin Type A and Modified Constraint-Induced Movement Therapy for Poststroke Upper Extremity Spasticity https://ClinicalTrials.gov/show/NCT00723866 Completed Kaohsiung Veterans General Hospital. 2007-11-30
NCT00711646 A Study of Sativex® for Relief of Spasticity in Subjects With Multiple Sclerosis. https://ClinicalTrials.gov/show/NCT00711646 Completed GW Pharmaceuticals Ltd. 2004-03-31
NCT00702468 Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasticity Due to Multiple Sclerosis https://ClinicalTrials.gov/show/NCT00702468 Completed GW Pharmaceuticals Ltd. 2009-01-31
NCT00681980 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) https://ClinicalTrials.gov/show/NCT00681980 Completed University of Sao Paulo 2009-09-30
NCT00681538 A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, From Phase B, With Multiple Sclerosis (MS) https://ClinicalTrials.gov/show/NCT00681538 Completed GW Pharmaceuticals Ltd. 2009-01-31
NCT00661089 Randomized DB Controlled Trial of Botulinum Toxin A in Hemiplegic Shoulder Pain and Spasticity https://ClinicalTrials.gov/show/NCT00661089 Completed Shirley Ryan AbilityLab 2009-03-31
NCT00651729 Safety Study of Botulinum Toxin Type A for the Treatment of Focal Upper Limb Poststroke Spasticity https://ClinicalTrials.gov/show/NCT00651729 Completed Allergan 2004-12-31
NCT00651690 Study of Responsiveness of Seven Functional Tasks in Patients With Poststroke Upper Limb Spasticity With Botulinum Toxin Type A Treatment https://ClinicalTrials.gov/show/NCT00651690 Completed Allergan 2005-05-31
NCT00632528 MEOPA to Improve Physical Therapy Results After Multilevel Surgery https://ClinicalTrials.gov/show/NCT00632528 Completed Assistance Publique - Hôpitaux de Paris 2011-03-31
NCT00623376 Randomized Double Blind Cross Over Study for Nabilone in Spasticity in Spinal Cord Injury Persons https://ClinicalTrials.gov/show/NCT00623376 Completed University of Manitoba 2007-11-30
NCT00607542 Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity https://ClinicalTrials.gov/show/NCT00607542 Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 2011-01-31
NCT00557973 A Safety and Efficacy Study of XP19986 in Subjects With Spasticity Due to Spinal Cord Injury https://ClinicalTrials.gov/show/NCT00557973 Completed Indivior Inc. 2009-04-30
NCT00549783 BOTOX® Economic Spasticity Trial (BEST) https://ClinicalTrials.gov/show/NCT00549783 Completed Allergan 2010-01-31
NCT00488839 IPX056 in Subjects With Established Spasticity Resulting From Multiple Sclerosis https://ClinicalTrials.gov/show/NCT00488839 Completed Impax Laboratories, LLC 2008-05-31
NCT00465738 IncobotulinumtoxinA (Xeomin) for Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT00465738 Completed Merz Pharmaceuticals GmbH 2008-01-31
NCT00462449 Efficacy of Functional Electrical Stimulation (FES) in Persons Receiving Botulinum Neurotoxin for Upper Extremity Spasticity https://ClinicalTrials.gov/show/NCT00462449 Completed University of Pittsburgh 2010-01-31
NCT00460655 Study of GSK1358820 In Patients With Post-Stroke Lower Limb Spasticity https://ClinicalTrials.gov/show/NCT00460655 Completed GlaxoSmithKline 2008-12-31
NCT00460564 Study Of GSK1358820 In Patients With Post-Stroke Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT00460564 Completed GlaxoSmithKline 2008-12-31
NCT00432666 IncobotulinumtoxinA (Xeomin) Versus Placebo in the Treatment of Post-stroke Spasticity of the Upper Limb https://ClinicalTrials.gov/show/NCT00432666 Completed Merz Pharmaceuticals GmbH 2006-11-30
NCT00430196 BOTOX® Versus Zanaflex® for the Treatment of Post-Stroke or Traumatic Brain Injury Upper Limb Spasticity https://ClinicalTrials.gov/show/NCT00430196 Completed Icahn School of Medicine at Mount Sinai NA
NCT00401154 Study of a Stationary Cycling Intervention for Children With Spastic Diplegic Cerebral Palsy https://ClinicalTrials.gov/show/NCT00401154 Completed University of Southern California 2006-03-31
NCT00367068 Dutch National ITB Study in Children With Cerebral Palsy https://ClinicalTrials.gov/show/NCT00367068 Completed Maastricht University Medical Center NA
NCT00324454 Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease https://ClinicalTrials.gov/show/NCT00324454 Completed Duke University 2007-12-31
NCT00248378 Short-Term Effects of Medicinal Cannabis Therapy on Spasticity in Multiple Sclerosis https://ClinicalTrials.gov/show/NCT00248378 Completed Center for Medicinal Cannabis Research NA
NCT00234546 Asian Botulinum Clinical Trial Designed for Early Stroke Spasticity https://ClinicalTrials.gov/show/NCT00234546 Completed Ipsen NA
NCT00223873 The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury https://ClinicalTrials.gov/show/NCT00223873 Completed VA Office of Research and Development NA
NCT00216411 Effects on Quality of Life Following Dysport Treatment in Post-stroke Spasticity of the Arm https://ClinicalTrials.gov/show/NCT00216411 Completed Ipsen 2006-07-20
NCT00199589 Treatment of Spastic Equinovarus Foot After Stroke https://ClinicalTrials.gov/show/NCT00199589 Completed University Hospital, Limoges NA
NCT00179114 Vanderbilt University Spasticity Management Program Evaluation Plan https://ClinicalTrials.gov/show/NCT00179114 Completed Vanderbilt University NA
NCT00178646 Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity https://ClinicalTrials.gov/show/NCT00178646 Completed The University of Texas Health Science Center, Houston 2010-03-31
NCT00133861 Botulinum Toxin Efficiency on Spasticity of Rectus Femoris and Semitendinosus Muscles as Functional Agonist and Antagonist Muscles https://ClinicalTrials.gov/show/NCT00133861 Completed Hospices Civils de Lyon 2008-06-30
NCT00076687 Safety Study of Botulinum Toxin Type A in Post-Upper Limb Stroke Patients With Reduced Lung Function https://ClinicalTrials.gov/show/NCT00076687 Completed Allergan 2009-08-31
NCT00076843 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis https://ClinicalTrials.gov/show/NCT00076843 Completed National Institutes of Health Clinical Center (CC) 2017-10-11
NCT00819065 Trial Comparing Two Commercial Formulations of Botulinum Toxin Type A in the Treatment of Spasticity https://ClinicalTrials.gov/show/NCT00819065 Completed Hospital de Clinicas de Porto Alegre 2010-05-31
NCT00060957 Botulinum Toxin (BOTOX) for Cerebral Palsy https://ClinicalTrials.gov/show/NCT00060957 Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 2002-06-30
NCT00047580 Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity. https://ClinicalTrials.gov/show/NCT00047580 Completed Elan Pharmaceuticals NA
NCT00041717 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury https://ClinicalTrials.gov/show/NCT00041717 Completed Acorda Therapeutics 2004-02-29
NCT00358293 Study of Nighttime Dosing of Sublingual Tizanidine (12 mg) in Multiple Sclerosis (MS) Patients With Significant Spasticity https://ClinicalTrials.gov/show/NCT00358293 Completed Teva GTC NA
NCT00011024 Prospective Studies of the Use of Self Hypnosis, Acupuncture and Osteopathic Manipulation on Muscle Tension in Children With Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT00011024 Completed National Center for Complementary and Integrative Health (NCCIH) NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03251521 Pain During Injection With Botulinum Toxin in Post-stroke Spasticity Treatment https://ClinicalTrials.gov/show/NCT03251521 Completed University Hospital, Grenoble 2013-07-31
NCT03250988 Prevalence of Comorbid Spasticity and Urinary Incontinence in Residents of a Long-Term Care Facility https://ClinicalTrials.gov/show/NCT03250988 Completed Vanderbilt University Medical Center 2018-08-01
NCT03211390 Using Telemedicine to Improve Spasticity Diagnosis Rates https://ClinicalTrials.gov/show/NCT03211390 Completed Vanderbilt University Medical Center 2018-08-01
NCT03209960 Validity and Inter-Rater Reliability of a Novel Bedside Referral Tool for Spasticity https://ClinicalTrials.gov/show/NCT03209960 Completed Vanderbilt University Medical Center 2018-08-01
NCT03112434 Muscle Elastography in Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03112434 Enrolling by invitation Hospital for Special Surgery, New York 2020-01-31
NCT03059342 Functional Follow-up After Single Event Multilevel Surgery in Children Spastic Diplegic Cerebral Palsy https://ClinicalTrials.gov/show/NCT03059342 Active, not recruiting Universitaire Ziekenhuizen Leuven 2019-12-31
NCT03017729 Effectiveness and Safety of Dysport® (abobotulinumtoxinA) in Paediatric Lower Limb Spasticity https://ClinicalTrials.gov/show/NCT03017729 Active, not recruiting Ipsen 2020-11-30
NCT02859428 Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31 https://ClinicalTrials.gov/show/NCT02859428 Recruiting National Institutes of Health Clinical Center (CC) 2028-12-31
NCT02852278 A Patient Centric Motor Neuron Disease Activities of Daily Living Scale https://ClinicalTrials.gov/show/NCT02852278 Completed University of South Florida 2019-09-13
NCT02454803 Attainment of Person-centred Goals After Botulinum Toxin Treatment for Upper Limb Spasticity in Real Life Practice https://ClinicalTrials.gov/show/NCT02454803 Completed Ipsen 2019-06-03
NCT02408900 Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function https://ClinicalTrials.gov/show/NCT02408900 Completed National Institutes of Health Clinical Center (CC) 2015-08-03
NCT02390206 Study on the Use of Botulinum Toxin Type A in the Treatment of Chronic Post-stroke Spastic Patients https://ClinicalTrials.gov/show/NCT02390206 Completed Ipsen 2017-08-28
NCT02384330 Botulinum Toxin A Associated Costs in the Treatment of Upper Limb Spasticity Post Stroke https://ClinicalTrials.gov/show/NCT02384330 Completed Ipsen 2017-03-16
NCT02275312 ETREAT Study on Effectiveness of Botulinum Toxin Type A Injections to Treat Post-stroke Upper and/or Lower Limb Spasticity https://ClinicalTrials.gov/show/NCT02275312 Completed Ipsen 2017-07-31
NCT03384927 Effect of Treatment Dairy for Spasticity https://ClinicalTrials.gov/show/NCT03384927 Enrolling by invitation Rigshospitalet, Denmark 2019-10-30
NCT02043145 Safety and Efficacy of BOTOX® (Botulinum Toxin Type A) in Korea https://ClinicalTrials.gov/show/NCT02043145 Completed Allergan 2012-04-30
NCT02020980 RELIEF Study: Lower Limb Pain Relief After Injection Cycles in Adults Suffering From Lower Limb Spasticity Following Stroke https://ClinicalTrials.gov/show/NCT02020980 Completed Ipsen 2018-03-05
NCT01930786 An Adult Spasticity Registry of OnabotulinumtoxinA Treatment https://ClinicalTrials.gov/show/NCT01930786 Completed Allergan 2017-10-09
NCT01879449 Prevalence of Spasticity in Veterans Living in a Long-term Care Facility https://ClinicalTrials.gov/show/NCT01879449 Completed Vanderbilt University 2014-05-31
NCT01840475 Arm Spasticity - Non-Interventional Study Early BIRD (BoNT Treatment: Initial and Repeated Documentation) https://ClinicalTrials.gov/show/NCT01840475 Completed Ipsen 2018-02-06
NCT01644123 Reliability of an Algorithm to Diagnose Spasticity https://ClinicalTrials.gov/show/NCT01644123 Completed Vanderbilt University 2016-01-31
NCT01587170 Effects of Zolmitriptan on Sensory Transmission After Spinal Cord Injury https://ClinicalTrials.gov/show/NCT01587170 Completed University of Alberta 2012-05-31
NCT01523210 DTI Study of the Influence of Physiotherapy on Distribution of BoNT in Spastic Muscle https://ClinicalTrials.gov/show/NCT01523210 Completed Medical University of Vienna 2012-11-30
NCT01444794 Adult Subjects Suffering From Lower Limb Spasticity Following Stroke https://ClinicalTrials.gov/show/NCT01444794 Completed Ipsen 2012-09-30
NCT01390922 Special Drug Use Investigation for Botox® (Botulinum) Spasticity (BOTOX is a Registered Trademark of Allergan, Inc.) https://ClinicalTrials.gov/show/NCT01390922 Completed GlaxoSmithKline 2014-10-31
NCT01387074 Observational Study of Botox® Treatment for Patients With Upper Limb Adult Spasticity https://ClinicalTrials.gov/show/NCT01387074 Completed Allergan 2013-01-31
NCT01383681 Retrospective Study of Patients With Spasticity in the Spanish Population https://ClinicalTrials.gov/show/NCT01383681 Completed Allergan 2012-10-31
NCT01332474 JCP Study of Investigation of Patient Background Characteristics https://ClinicalTrials.gov/show/NCT01332474 Completed GlaxoSmithKline 2010-08-31
NCT04404868 Early Treatment of Post-stroke Spasticity With Botulinum Toxin https://ClinicalTrials.gov/show/NCT04404868 Completed Universita di Verona 2018-12-31
NCT04266964 Validity and Reliability Study of the Muscle Excitability Scale in Spinal Cord Injury Patients https://ClinicalTrials.gov/show/NCT04266964 Recruiting University Hospital, Motol 2020-11-30
NCT04265092 Therapeutic Benefit of Incobotulinum Toxin A for Spasticity of the Triceps Surae in Patients With Multiple Sclerosis https://ClinicalTrials.gov/show/NCT04265092 Completed Pôle Saint Hélier 2014-03-31
NCT04231227 The Validity and Reliability of the Turkish Version of TASC and the Relationship Between SMC and Motor Functions https://ClinicalTrials.gov/show/NCT04231227 Completed Gazi University 2018-09-30
NCT04090892 Effects of Soft Tissue Lengthening on Gait in Children With Spasticity https://ClinicalTrials.gov/show/NCT04090892 Completed University of Texas Southwestern Medical Center 2017-01-31
NCT04050527 Study to Assess the Effectiveness of AboBoNT-A Injections for Adult Lower Limb Spasticity in a Real Life Cohort https://ClinicalTrials.gov/show/NCT04050527 Recruiting Ipsen 2022-02-28
NCT04036981 Muscle Selection for Botulinum Toxin A Injection in Poststroke Elbow Flexor Spasticity https://ClinicalTrials.gov/show/NCT04036981 Recruiting Izmir Katip Celebi University 2020-05-31
NCT04022187 Assessment of the Excitability of Spinal Motoneurons Using Stimulus-response Curves of the Bulbocavernosus Reflex https://ClinicalTrials.gov/show/NCT04022187 Recruiting Pierre and Marie Curie University 2019-07-11
NCT03995524 Spasticity and Treatment Satisfaction Among Stroke Survivors https://ClinicalTrials.gov/show/NCT03995524 Completed Ipsen 2020-05-12
NCT03888443 “Be an Airplane Pilot”: A Bimanual 3D Motion Analysis in Children With Unilateral Cerebral Palsy https://ClinicalTrials.gov/show/NCT03888443 Completed Rennes University Hospital 2019-06-26
NCT03886753 Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products https://ClinicalTrials.gov/show/NCT03886753 Active, not recruiting Children’s Hospital of Philadelphia 2020-12-31
NCT03859960 The Effects of Spasticity on Glucose Metabolism in Individuals With Spinal Cord Injury https://ClinicalTrials.gov/show/NCT03859960 Completed Fatih Sultan Mehmet Training and Research Hospital 2018-05-10
NCT03814460 Stroke and Assessment of Muscle Tone https://ClinicalTrials.gov/show/NCT03814460 Completed University of Seville 2019-08-25
NCT03660969 Reliability of Cardiac Troponins for the Diagnosis of Myocardial Infarction in the Presence of Skeletal Muscle Disease https://ClinicalTrials.gov/show/NCT03660969 Recruiting University Hospital, Basel, Switzerland 2022-01-01
NCT03588832 Prevalence of Postural Patterns of Upper Extremity. https://ClinicalTrials.gov/show/NCT03588832 Completed Universidad de la Frontera 2019-03-30
NCT03563209 Assesment of Post-stroke Elbow Flexor Spasticity in Different Forearm Positions https://ClinicalTrials.gov/show/NCT03563209 Completed Izmir Katip Celebi University 2018-08-15
NCT03462693 Dry Needling in Stroke in Sub-Acute Phase to Improve Upper Limb https://ClinicalTrials.gov/show/NCT03462693 Completed Guadarrama Hospital 2018-10-25
NCT03421509 Cutaneous Silent Period and Spasticity https://ClinicalTrials.gov/show/NCT03421509 Recruiting Marmara University 2019-01-01
NCT01265238 Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus Foot https://ClinicalTrials.gov/show/NCT01265238 Completed University Hospital of Mont-Godinne 2012-03-31
NCT01020500 To Document the Effectiveness of BoNT-A Injection in Adult Subjects With Upper Limb Spasticity Following Stroke https://ClinicalTrials.gov/show/NCT01020500 Completed Ipsen 2011-05-31
NCT04294407 Using the Movement and Electromyographical Analyses to Assess the Muscle Spasticity https://ClinicalTrials.gov/show/NCT04294407 Recruiting National Cheng-Kung University Hospital 2022-12-31
NCT01509885 Cyproheptadine and Chlorpromazine Effects on Spasticity https://ClinicalTrials.gov/show/NCT01509885 Completed University of Alberta 2012-11-30
NCT00575536 Optical Stimulation in Peripheral Nerves for Select Rhizotomy Procedures https://ClinicalTrials.gov/show/NCT00575536 Completed Vanderbilt University 2017-11-30
NCT00535938 MDs on Botox Utility (MOBILITY) https://ClinicalTrials.gov/show/NCT00535938 Completed Allergan 2013-09-30
NCT00337688 Power Wheelchair Joystick Use in Spastic Cerebral Palsy https://ClinicalTrials.gov/show/NCT00337688 Completed University of Pittsburgh 2008-06-30
NCT00282191 Prevalence of Spasticity in Adults With Mental Retardation Living in the Community https://ClinicalTrials.gov/show/NCT00282191 Completed Vanderbilt University 2007-08-31
NCT00210431 Post Marketing Surveillance Study of Dysport https://ClinicalTrials.gov/show/NCT00210431 Completed Ipsen NA
NCT00034723 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis https://ClinicalTrials.gov/show/NCT00034723 Completed National Institutes of Health Clinical Center (CC) NA
NCT00024791 Eye-Hand Coordination in Children With Spastic Diplegia https://ClinicalTrials.gov/show/NCT00024791 Completed National Institutes of Health Clinical Center (CC) NA
NCT00023075 Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis https://ClinicalTrials.gov/show/NCT00023075 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001156 Assessment of Patients With Multiple Sclerosis (MS) https://ClinicalTrials.gov/show/NCT00001156 Completed National Institutes of Health Clinical Center (CC) NA
NCT00014976 Physiologic Studies of Spasticity https://ClinicalTrials.gov/show/NCT00014976 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03248986 Dry Needling in Stroke to Improve the Upper Limb Functionality https://ClinicalTrials.gov/show/NCT03248986 Completed Guadarrama Hospital 2017-10-31
NCT02444494 Study to Document the Effectiveness of Dysport in Patients Suffering From Upper Limb Spasticity (ULS) After Stroke https://ClinicalTrials.gov/show/NCT02444494 Completed Ipsen 2016-09-30
NCT04006418 A Registered Cohort Study on Spastic Paraplegia https://ClinicalTrials.gov/show/NCT04006418 Recruiting First Affiliated Hospital of Fujian Medical University 2039-12-31
NCT03981276 Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders https://ClinicalTrials.gov/show/NCT03981276 Recruiting University Hospital Tuebingen 2039-08-31
NCT03459066 Predictors Factors and Time of Onset of Spasticity and Their Relationship With the Functionality and Quality of Life. https://ClinicalTrials.gov/show/NCT03459066 Active, not recruiting Universidad de la Frontera 2019-03-30
NCT01793168 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford https://ClinicalTrials.gov/show/NCT01793168 Recruiting Sanford Health 2100-12-31